C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/42 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01) A61K 31/335 (2006.01) C07C 255/41 (2006.01) C07C 255/57 (2006.01) C07C 259/10 (2006.01) C07C 317/44 (2006.01) C07D 317/60 (2006.01) C07D 319/18 (2006.01)
Patent
CA 2231465
2-Acylbenzamide derivatives represented by general formula (I), (wherein R1, R2, R3, R4 and R5 represent each hydrogen, etc.; X represents vinylene, etc.; and B represents -N(R6) (R7) (wherein R6 and R7 represent each hydrogen, etc.), -NH-(CH2)n-A-R8 (wherein A represents a single bond, etc.; and R8 represents hydroxy, etc.) or hydroxyamino, which is useful as a preventive and remedy for diseases caused by the supermultiplication of vascular intimal cells.
Dérivés de 2-Acylbenzamide représentés par la formule générale (I). Dans cette formule, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ représentent indépendamment hydrogène, etc.; X représente le vinylène, etc.; et B représente -N(R?6¿) (R?7¿) (R?6¿ et R?7¿ représentant indépendamment hydrogène, etc.), -NH-(CH¿2?)¿n?-A-R?8¿ (où A représente une liaison unique, etc.; et R?8¿ représente hydroxy, etc. ou hydroxyamino). Ces dérivés se révèlent utiles pour prévenir ou soigner les maladies causées par une surmultiplication des cellules vasculaires de l'intima.
Fujikura Hideki
Harada Hiromu
Hotei Yukihiko
Iyobe Akira
Kamata Koji
Kirby Eades Gale Baker
Kissei Pharmaceutical Co. Ltd.
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