(2-acylaminothiazole-4-yl)acetic acid derivatives

C - Chemistry – Metallurgy – 07 – D

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C07D 277/46 (2006.01) A61K 31/425 (2006.01) A61K 31/426 (2006.01)

Patent

CA 2330558

This invention provides compounds of Formula (I) having structure (I), wherein R1, R2 are both hydrogen or form a bond, or are each, independently, alkyl of 1-6 carbon atoms or aryl of 6-12 carbon atoms; m = 0-10; n = 1-3; and p = 0- 10; with the proviso that m + p is less than or equal to 15; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

La présente invention concerne des composés de formule (I) de structure (I), dans laquelle R?1¿, R?2¿ sont tous les deux des hydrogènes ou forment une liaison, ou sont chacun, de manière indépendante, un alkyle en C¿1?-C¿6? ou un aryle en C¿6?-C¿12?; m prend la valeur de 0 à 10, n prend la valeur de 1 à 3, et p prend la valeur de 0 à 10 ; avec la condition que la somme m+p soit inférieure ou égale à 15. Ces composés ou leurs sels acceptables sur le plan pharmaceutique sont utiles dans le traitement de la résistance insulinique et de l'hyperglycémie.

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