C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/211, 167/255
C07C 219/06 (2006.01) A61K 31/22 (2006.01) C07C 323/25 (2006.01) C07D 295/088 (2006.01) C07D 295/15 (2006.01)
Patent
CA 1318670
ABSTRACT The present invention provides 2-acyloxypropyl-amine compounds of the general formula I Image (I) wherein R1 is a straight-chained or branched, saturated or unsaturated aliphatic radical containing up to 20 carbon atoms, R2 is a straight-chained or branched alkyl radical containing up to 4 carbon atoms, R3 and R4, which can be the same or different, are hydrogen atoms or straight-chained or branched alkyl radicals containing up to 14 carbon atoms which are optionally substituted by phenyl or R3 and R4 together form a piperidine or piperazine ring which is optionally substituted by alkyl radicals containing up to 4 carbon atoms and X is an oxygen or sulphur atom; and the pharmacologically acceptable salts thereof. The present invention also provides processes for preparing these compounds and pharmaceutical compositions containing them. The compounds inhibit protein kinase C (PKC) and the thrombooyte aggregation stimulated by diacylglycerols.
543124
Mannhardt Karl
Marme Dieter
Rudolph Claus
Schachtele Christoph
Trostmann Uwe
Godecke Aktiengesellschaft
Mannhardt Karl
Marme Dieter
Rudolph Claus
Schachtele Christoph
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