A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/135 (2006.01) A61K 31/13 (2006.01) A61K 31/131 (2006.01) A61K 31/381 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61P 9/10 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01) A61P 25/30 (2006.01) A61P 25/32 (2006.01) A61P 25/34 (2006.01) A61P 25/36 (2006.01) A61P 27/00 (2006.01) C07C 211/04 (2006.01) C07C 211/27 (2006.01) C07C 211/29 (2006.01) C07C 217/60 (2006.01) C07D 333/10 (2006.01) C07D 333/20 (2006.0
Patent
CA 2360674
The use of a compound of formula (1), wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl and aryl, or pharmaceutically acceptable salts thereof, with the proviso that wherein R1 to R4 and R6 are hydrogen, R5 is not selected from CH2CH2NHSO2CH3, CH2CH2NHSO2CF3 and methyl substituted by SO2NH2, SO3H, PO3H2, CONHOH or a heterocyclic group selected from formulae (a), (b), (c), (d) and (e) in the manufacture of a medicament for use in the treatment of a condition generally associated with abnormalities in glutamatergic transmission.
L'invention concerne l'utilisation d'un composé correspondant à la formule (1) dans la réalisation d'un médicament destiné au traitement d'un état généralement associé à des anomalies de la transmission glutamatergique. Dans la formule (1), R¿1?, R¿2?, R¿3?, R¿4?, R¿5? et R¿6? sont choisis indépendamment parmi hydrogène, alkyle et aryle, ou un de leurs sels pharmaceutiquement acceptables, à condition que si R¿1?, R¿2?, R¿3?, R¿4? et R¿6? sont hydrogène, R¿5? n'est pas choisi parmi CH¿2?CH¿2?NHSO¿2?CH¿3?, CH¿2?CH¿2?NHSO¿2?CF¿3? et méthyle substitué par SO¿2?NH¿2?, SO¿3?H, PO¿3?H¿2?, CONHOH ou un groupe hétérocyclique sélectionné dans les formules (a), (b), (c), (d) et (e).
Bird Andrew James
Gillespie Roger John
Monck Nathaniel Julius Thomas
Ward Simon Edward
Kirby Eades Gale Baker
Vernalis Research Limited
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