2-adamantyl-butyramide derivatives as selective...

Details 2-adamantyl-butyramide derivatives as selective... 2-adamantyl-butyramide derivatives as selective...

C - Chemistry, Metallurgy

07

C

C07C 233/06 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/194 (2006.01) A61K 31/41 (2006.01) A61K 31/4245 (2006.01) A61K 31/426 (2006.01) A61K 31/4402 (2006.01) A61K 31/4453 (2006.01) C07C 233/08 (2006.01) C07C 233/13 (2006.01) C07C 233/15 (2006.01) C07C 233/23 (2006.01) C07C 233/26 (2006.01) C07C 235/22 (2006.01)

Patent

CA 2673430

The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11.beta.-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

La présente invention concerne des dérivés de 2-adamantyle-butyramide de formule I en tant qu'inhibiteurs sélectifs de l'enzyme 11-bêta-hydroxystéroïde déhydrogénase de type 1 (11.beta.-HSD-1). L'invention concerne également l'utilisation de tels composés dans le traitement et la prévention du syndrome métabolique, du diabète, de la résistance à l'insuline, de l'obésité, des troubles lipidiques, du glaucome, de l'ostéoporose, des troubles cognitifs, de l'anxiété, de la dépression, des troubles immuns, de l'hypertension et d'autres maladies et états.

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