C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 275/28 (2006.01) A61K 31/17 (2006.01) A61K 31/24 (2006.01) A61K 31/381 (2006.01) A61K 31/4409 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07C 275/26 (2006.01) C07C 275/30 (2006.01) C07C 275/34 (2006.01) C07C 321/28 (2006.01) C07D 213/75 (2006.01) C07D 261/14 (2006.01) C07D 319/08 (2006.01) C07D 333/36 (2006.01)
Patent
CA 2633186
The present invention relates to 2-adamantylurea derivatives of formula (I) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1(110-HSD1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
La présente invention concerne des dérivés de 2-adamantylurée de formule (I) en tant qu'inhibiteurs sélectifs de l'enzyme 11-bêta-hydroxystéroïde déshydrogénase de type 1 (11ß-HSD1) ainsi que l'emploi de tels composés dans le traitement prophylactique et thérapeutique du syndrome métabolique, du diabète, de l'insulinorésistance, de l'obésité, des troubles lipidiques, du glaucome, de l'ostéoporose, des troubles cognitifs, de l'anxiété, de la dépression, des troubles immuns, de l'hypertension et d'autres maladies et états pathologiques.
Carniato Denis
Charon Christine
Gleitz Johannes
Hock Bjoern
Roche Didier
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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