2-alkoxy-n-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and...

Details 2-alkoxy-n-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and... 2-alkoxy-n-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and...

A - Human Necessities

61

K

167/228

A61K 31/435 (2006.01) A61K 31/415 (2006.01) C07D 453/02 (2006.01)

Patent

CA 1284953

2-ALKOXY-N-(1-AZABICYCLO[2.2.2]OCT-3-YL) BENZAMIDES AND THIOBENZAMIDES IN A METHOD FOR ALLEVIATING EMESIS CAUSED BY NON-PLATINUM ANTICANCER DRUGS ABSTRACT OF THE INVENTION A composition for alleviating emesis caused by non-platinum anti-cancer drugs with 2-alkoxy-N-(1-azabicyclo[2.2.2]oct- 3-yl)benzamides and thiobenzamides having the formula Image wherein X is oxygen or sulfur; R1 is loweralkyl; and R2 is selected from the group consisting of hydrogen, halo, 4,5-benzo, methylsulfonyl, loweralkoxy or Am and n is 1 or 2, and the pharmaceutically acceptable acid addition salts thereof is disclosed.

531081

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