2-alkoxyphenyl substituted imidazotriazinones

Details 2-alkoxyphenyl substituted imidazotriazinones 2-alkoxyphenyl substituted imidazotriazinones

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 9/08 (2006.01)

Patent

CA 2438113

The invention relates to 2-phenyl substituted imidazotriazinones comprising short, non-branched alkyl radicals in position 9, which are produced from the corresponding 2-phenyl imidazotriazinones by means of chlorosulfonation and subsequently reacted with the amines. The components inhibit cGMP-metabolised phosphodiesterases and are suitable for use as active ingredients in medicaments for treating cardiovascular and cerebrovascular diseases and/or diseases of the urogenital system, particularly for treating erectile dysfunctions.

L'invention concerne des imidazotriazinones 2-phényl-substituées à restes alkyle courts et non ramifiés en position 9, qui sont produites à partir des 2-phényl-imidazotriazinones correspondantes par chlorosulfonation puis réaction consécutive avec des amines. Ces composés inhibent des phosphodiestérases métabolisant le cGMP et conviennent comme principes actifs dans des médicaments pour le traitement d'affections cardiovasculaires et cérébrovasculaires ou d'affections de l'appareil urogénital, notamment pour le traitement du dysfonctionnement érectile.

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