C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2734077
The invention relates to 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2- b]pyridazine derivatives of the general formula (I) where: R2 is a C1-6-alkyl, C3.7-cycloalkyl, C3-7-cycloalkyl-C1-4-alkyl, C1-4-alkyloxy- C-M-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl> C3.7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-4-fluoroalkyl group; R3 is a hydrogen atom or a substituent selected from halogen atoms and the C1-3 alkyl, -NR4R5, hydroxyl or C1-4 alkyloxy groups ; A is a C-1-7-alkylene group optionally substituted by one or two Ra groups; B is a C-1-7-alkylene group optionally substituted by one or two Rb groups; L is either a nitrogen atom optionally substituted by an Rc or Rd group or a carbon atom substituted by an Re1 group and an Rd group or by two Re2 groups; Rd is a group selected from a hydrogen atom or a C1-6-alkyl, C3-7-cycloalkyl, C3-7- cycloalkyl-C1-6-alkyl, C1-6-alkylthio-C-1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C1- 6-fluoroalkyl, hydroxy-C1-6-alkyl group; Rf is a C1-6-alkyl, C3-7-cycloalkyl, C3-7-cycloalkyl-C1-6-alkyl, C1-6-alkyloxy-C1-6-alkyl, C3-7-cycloalkyloxy-C1-4-alkyl, C3-7- cycloalkyl-C1-4-alkyloxy-C1-4-alkyl, hydroxy-C1-6-alkyl, C1-6-fluoroalkyl or benzyl group. The invention also relates to a method for preparing same and to the therapeutic application thereof.
L'invention concerne des dérivés de 2-alkyl-6-cycloamino-3-(pyridin-4- yl)imidazo[1,2- b]pyridazine, répondant à la formule générale (I) dans laquelle R2 représente un groupe C1-6-alkyle, C3-7- cycloalkyle, C3-7 -cycloalkyl-C1-4 -alkyle, C1-4-alkyloxy- C-M-alkyle, C3-7-cycloalkyloxy-C1-4-alkyle > C3-7-cycloalkyl-C1-4-alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-4-fluoroalkyle; R3 représente un atome d'hydrogène ou un substituant choisi parmi les atomes d'halogène et les groupes C1-3 alkyle, -NR4R5, hydroxyle ou C1-4 alkyloxy; A représente un groupe C-1-7-alkylène éventuellement substitué par un ou deux groupes R a; B représente un groupe C1-7-alkylène éventuellement substitué par un groupe R b; L représente soit un atome d'azote éventuellement substitué par un groupe R c ou R d, soit un atome de carbone substitué par un groupe R e1 et un groupe R d ou deux groupes R e2; R d représente un groupe choisi parmi l'atome d'hydrogène et les groupes C1-6- alkyle, C3-7-cycloalkyle, C3-7- cycloalkyl-C1-6-alkyle, C1-6-alkylthio-C-1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C1-6-fluoroalkyle, hydroxy-C1-6-alkyle; R f représente un groupe C1-6-alkyle, C3-7-cycloalkyle, C3-7-cycloalkyle-C1-6-alkyle, C1-6-alkyloxy-C1-6-alkyle, C3- 7-cycloalkyloxy-C1-4-alkyle, C3-7- cycloalkyl-C1-4- alkyloxy-C1-4-alkyle, hydroxy-C1-6-alkyle, C1-6-fluoroalkyle ou benzyle. Procédé de préparation et application en thérapeutique.
Almario Garcia Antonio
Burnier Philippe
Chiang Yulin
Cote-Des Combes Sylvain
Davis Larry
Robic
Sanofi-Aventis
LandOfFree
2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-ib]-pyridaz... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-ib]-pyridaz..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-alkyl-6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-ib]-pyridaz... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1497498