C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01) A61K 31/454 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) C07D 413/04 (2006.01)
Patent
CA 2758731
The present invention is directed to 2-alkylpiperidines which are positive allosteric modulators of metabotropic glutamate receptors, particularly the mGluR5 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
La présente invention porte sur des 2-alkyl pipéridines, qui sont des modulateurs allostériques positifs des récepteurs métabotropiques du glutamate, en particulier le récepteur MGluR5, et qui sont utiles dans le traitement ou la prévention de troubles neurologiques et psychiatriques associés à un dysfonctionnement du glutamate, et de maladies dans lesquelles sont impliqués les récepteurs métabotropiques du glutamate. L'invention porte aussi sur des compositions pharmaceutiques comprenant ces composés, et sur l'utilisation de ces composés et compositions pour prévenir ou traiter des maladies dans lesquelles sont impliqués les récepteurs métabotropiques du glutamate.
Mercer Swati P.
Roecker Anthony J.
Williams Theresa
Zhang Xu-Fang
Merck Sharp & Dohme Corp.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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