2-alkylated-cyclodextrin derivatives: reversal agents for...

C - Chemistry – Metallurgy – 08 – B

Patent

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Details

C08B 37/16 (2006.01) A61K 31/715 (2006.01) A61K 31/724 (2006.01)

Patent

CA 2437851

Disclosed is a 2-alkylated-cyclodextrin derivative having the general formula I wherein m is 0-7 and n is 1-8 and m+n= 7 or 8; R is (CH2)p-phenylene-(CH2)q, (C1-6)alkylene, or (CH2)r-S-(C1-4)alkylene, of which each alkylene group may be substituted with 1-3 OH groups; p and r are independently 1-4; q is 0-4; X is COOH, SO2OH, (CH2-CH2-O)s-H or OH; s is 1-3; or a pharmaceutically acceptable salt thereof. The 2-alkylated-cyclodextrin derivatives are suitable for use in the reversal of drug-induced neuromuscular block.

L'invention se rapporte à un dérivé de la cyclodextrine 2-alkylée représenté par la formule générale (I), dans laquelle m est compris entre 0 et 7 et n est compris entre 1 et 8 et m+n=7 ou 8 ; R est (CH¿2?)¿p?-phénylène-(CH¿2?)¿q?, alkylène(C¿1-6?), alkylène(CH¿2?)¿r?-S-(C¿1-4?) dont chaque groupe alkylène peut être substitué par 1 à 3 groupes OH; p et r sont indépendamment compris entre 1 et 4; q est compris entre 0 et 4; X est COOH, SO¿2?OH, (CH¿2?-CH¿2?-O)¿s?-H ou OH; s est compris entre 1 et 3. L'invention se rapporte également à un sel pharmaceutiquement acceptable de ce dérivé. Les dérivés de cyclodextrine 2-alkylée peuvent être utilisés pour réaliser une inversion d'un blocage neuromusculaire d'origine médicamenteuse.

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