2'-alkylidenepyrimidine nucleoside derivatives, process for...

Details 2'-alkylidenepyrimidine nucleoside derivatives, process for... 2'-alkylidenepyrimidine nucleoside derivatives, process for...

C - Chemistry, Metallurgy

07

H

167/202, 260/229

C07H 19/06 (2006.01) A61K 31/70 (2006.01) C07H 19/073 (2006.01)

Patent

CA 1319932

ABSTRACT OF THE DISCLOSURE Disclosed are novel 2'-alkylidenepyrimidine nucleoside derivatives represented by formula [I]: Image [I] wherein Rl is an amino group or a hydroxy group, R2 is a hydrogen atom, a halogen atom or a lower alkyl group, R3 is a hydrogen atom or a lower alkyl group, and R4 is a hydrogen atom or a phosphate residue, or salts thereof. These novel compounds can be produced from uridine or cytidine derivatives by alkylidenating the 2'-position in the sugar moiety thereof with Wittig's reagent. Furthermore, the compounds have remarkable antiviral activities and therefore can provide novel antiviral agents.

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