2-(.alpha.-phenyltolyl)azacycloalkanes, -azacycloalkenes,...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/04 (2006.01) C07D 207/12 (2006.01) C07D 211/06 (2006.01) C07D 211/12 (2006.01) C07D 211/14 (2006.01) C07D 211/16 (2006.01) C07D 211/18 (2006.01) C07D 211/22 (2006.01) C07D 211/52 (2006.01) C07D 211/70 (2006.01) C07D 211/94 (2006.01)

Patent

CA 1103677

Abstract of the Disclosure Compounds of the formula 1 Image wherein X is C-R4 or C; Y is -(CH2)n- when X is CR4 and =CH-(CH2)n-1- when X is C; R is hydrogen, lower alkyl, phenyl- loweralkyl of the formula Image wherein p is 1, 2, 3 or 4 and R1 is hydrogen or halogen, hydroxy, benzoylloweralkyl of the formula Image wherein p and R1 are as defined above; phenyloxycarbonyl, benzoyl, benzoyloxy or Image ; wherein p and R1 are as defined above, R2 and R3 are the same or different and each can be hydrogen, halogen, alkoxy of from 1 to 2 carbon atoms, lower alkyl and hydroxy; R4 is hydrogen or OR5; R5 is hydrogen, loweracyl, benzoyl or cycloalkanoyl in which the cycloalkyl ring contains from 3 to 6 carbon atoms; m is the integer 1 or 2; n is the integer 1, 2 or 3; the sum of m and n is 3 or 4; and the pharmaceutically acceptable acid addition salts thereof, and a process for the preparation thereof. The compounds are useful as antidepressants, anticonvulsants, tranquilizers and analgetics.

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