C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61P 31/14 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07K 5/10 (2006.01)
Patent
CA 2536436
The present invention relates to compounds of formula I-A and I-B that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3- NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivouse or for administration to a patient suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.
Cette invention concerne des composés inhibant l'activité des sérines protéases, plus particulièrement, l'activité de la protéase NS3-NS4A du virus de l'hépatite C (VHC). Lesdits composés agissent en intervenant dans le cycle de vie du virus de l'hépatite C, et sont utilisés comme agents antiviraux. Cette invention concerne également des composition comprenant ces composés, soit pour une utilisation ex vivo, soit pour une administration à un patient souffrant d'une infection à VHC. Cete invention concerne également des méthodes permettant de traiter une infection à VHC chez un patient, par administration d'une composition comprenant le composé décrit dans l'invention. En outre, on décrit des procédés permettant d'élaborer ces composés.
Britt Shawn D.
Court John J.
Perni Robert B.
Pitlik Janos
Van Drie John H.
Smart & Biggar
Vertex Pharmaceuticals Incorporated
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