2'-amido and 2'-peptido modified oligonucleotides

Details 2'-amido and 2'-peptido modified oligonucleotides 2'-amido and 2'-peptido modified oligonucleotides

C - Chemistry, Metallurgy

12

N

C12N 9/22 (2006.01) C07H 21/00 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2174339

Oligonucleotide comprising a nucleotide base having formula (I) wherein B is a nucleotide base or hydrogen; R1 and R2 indepently are selected from the group consisting of hydrogen, an alkyl group containing between 2 and 10 carbon atoms inclusive, an amine, an amino acid, and a peptide containing between 2 and 5 amino acids inclusive; and the zigzag lines are independently hydrogen or a bond.

Oligonucléotide comprenant une base nucléotide de formule (I) où B est une base nucléotide ou hydrogène; R¿1? et R¿2? sont indépendamment choisis parmi hydrogène, un groupe alkyle comprenant entre 2 et 10 atomes de carbone (inclusivement), une amine, un acide aminé, et un peptide comprenant entre 2 et 5 acides aminés (inclusivement); et où les lignes en zigzag sont indépendamment hydrogène ou une liaison.

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