2-amino 1h imidazo ring systems and methods

Details 2-amino 1h imidazo ring systems and methods 2-amino 1h imidazo ring systems and methods

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4745 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2578975

1H-Imidazo ring systems (e.g., imidazopyridines, imidazoquinolines, imidazonaphthyridines, 6,7,8,9-tetrahydro imidazoquinolines and imidazonaphthyridines) with an amino substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

La présente invention concerne des systèmes cycliques 1<I>H</I>-Imidazo (tels que des imidazopyridines, des imidazoquinolines, des imidazonaphthyridines, des 6,7,8,9-tétrahydro imidazoquinolines et des imidazonaphthyridines) comportant un substituant amino en position 2, des compositions pharmaceutiques contenant ces composés, des procédés de production de ces composés, des intermédiaires et l'utilisation de ces composés comme immunomodulateurs pour moduler la biosynthèse de cytokine chez des animaux et pour traiter certaines maladies, y compris des maladies virales et néoplasiques.

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