[[2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid...

Details [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid... [[2-(amino-3,4-dioxo-1-cyclobuten-1-yl)amino]alkyl]-acid...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/195 (2006.01) A61K 31/42 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 31/66 (2006.01) C07C 229/16 (2006.01) C07C 229/46 (2006.01) C07D 241/38 (2006.01) C07D 243/10 (2006.01) C07D 271/07 (2006.01) C07D 403/06 (2006.01) C07F 9/40 (2006.01) C07F 9/645 (2006.01) C07F 9/6509 (2006.01)

Patent

CA 2059704

A compound of the formula: Image in which R1 is hydrogen, alkyl or phenylalkyl; R2 is hydrogen, alkyl, alkenyl or phenylalkyl; or R1 and R2 taken together are -CH2CH2-, -CH2C(R6)(R7)CH2- or -CH2C(R8)(R9)-C(R10)(R11)CH2-, where R6, R8 and R10 are, independently, hydrogen, alkyl of 1 to 6 carbon atoms or hydroxyl and R7, R9 and R11 are, independently, hydrogen or alkyl of 1 to 6 carbon atoms; A is alkylene or alkenylene; X is CO2R3 in which R3 is hydrogen or alkyl, P(O)(OR4)(OR5) in which R4 and R5 are, independently, hydrogen or alkyl, 3,5-dioxo-1,2,4-oxadiazolidin-2-yl or 5- tetrazolyl; or a pharmaceutically acceptable salt thereof are useful as neuroprotectants.

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