2-amino-3(4 or 5)-pyridinyl)-phenols, preparation and...

Details 2-amino-3(4 or 5)-pyridinyl)-phenols, preparation and... 2-amino-3(4 or 5)-pyridinyl)-phenols, preparation and...

C - Chemistry, Metallurgy

07

D

260/296, 260/297

C07D 213/30 (2006.01)

Patent

CA 1136632

ABSTRACT OF THE DISCLOSURE 2-Amino-3(4 or 5)-PY-phenol, a cardiotonic agent, is prepared by reducing 2-nitro-3(4 or 5)-PY-phenol, where PY is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. 2-Amino-3(4 or 5)-PY-phenol or pharmaceutically-acceptable acid-addition salt thereof is disclosed as the active component in a cardiotonic compo- sition for increasing cardiac contractility and in the method for increasing cardiac contractility in a patient reguiring such treatment. The novel isomeric 4-amino-5-(4- pyridinyl)phenol is shown for comparative purposes.

382047

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