2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters...

Details 2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters... 2-amino-3-[hydroxy(phenyl)methyl] phenylacetic acids, esters...

C - Chemistry, Metallurgy

07

D

260/552.3, 260/2

C07D 295/18 (2006.01) C07D 295/185 (2006.01)

Patent

CA 1156655

ABSTRACT OF THE INVENTION 2-Amino-3-[hydroxy(phenyl)methyl]phenylacetic acids, metal salts and hydrates thereof, esters and amides having the formula Image are disclosed wherein R1 is hydrogen or loweralkyl; R2 is OH, OM, -O-loweralkyl or -NR3R4; R3 and R4 are hydrogen, loweralkyl, cycloslkyl, phenyl, and phenyl substituted by loweralkyl, loweralkoxy, halogen or trifluoromethyl and R3 and R4 taken together with the adjacent nitrogen may form a heterocyclic residue; M is a pharmaceutically acceptable cation or fraction thereof when the cation is multivalent; Am is primary amino or dimethylamino; X is hydrogen, halogen, loweralkyl, loweralkoxy, trifluoromethyl or methyl- thio; and n is 1 to 3 inclusive and when n is greater than one, Y may be the same or different and hydrates of all. The compounds have anti-inflammatory, anti-pyretic, analgesic and blood-platelet-aggregation-inhibiting activities.

371185

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