2-amino-3-hydroxyphenyl-3-butenoic acid derivatives

Details 2-amino-3-hydroxyphenyl-3-butenoic acid derivatives 2-amino-3-hydroxyphenyl-3-butenoic acid derivatives

C - Chemistry, Metallurgy

07

D

260/516.2, 260/4

C07D 309/12 (2006.01) A61K 31/195 (2006.01) C07C 45/63 (2006.01) C07C 45/67 (2006.01)

Patent

CA 1190242

Abstract of the Disclosure Compounds of the formula: Image wherein: X is fluorine, chlorine, or bromine, and R is a group of the formula: Image Image wherein R3 is hydrogen, (C1-C4)alkyl, or (C1-C4)alkoxy, and R4 is (C1-C4)alkyl or (C1-C4)alkoxy; or a (C1-C8)alkyl ester thereof; or a non-toxic pharmaceutically acceptable salt thereof; inhibit MAO in vivo and can be administered either alone or in combination with an aromatic L-amino acid decarboxylase inhibitor for the treatment of depression.

403964

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