2-amino-5-hydroxy-4-pyrimidones

Details 2-amino-5-hydroxy-4-pyrimidones 2-amino-5-hydroxy-4-pyrimidones

C - Chemistry, Metallurgy

07

D

167/222, 260/255

C07D 239/54 (2006.01) A61K 31/505 (2006.01) C07D 239/545 (2006.01) C07D 403/04 (2006.01)

Patent

CA 1310642

F.C. 7235/A 2-AMINO-5-HYDROXY-4-PYRIMIDONES Abstract A compound of the formula Image I or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen; R2 is (C1-C15)alkyl, (C3-C15)alkenyl, phenyl, substituted phenyl, (C7-C20)- phenylalkyl, or substituted (C7-C20)phenylalkyl wherein the substituents on the substituted phenyl and sub- stituted phenylalkyl are independently one or two of fluoro, chloro, (C1-C3)alkyl, (C1-C3)alkoxy, and trifluoromethyl; or R1 and R2 together with the nitrogen atom to which they are attached form a pyrrolidinyl, substituted pyrrolidinyl, piperidyl or substituted piperidyl group, wherein the substituents on said substituted pyrrolidinyl and piperidyl groups are independently one of (C1-C6)alkyl, phenyl, and (C7-C9)phenylalkyl; and R3 is hydrogen, (C1-C6)alkyl, phenyl, substituted phenyl, (C7-C9)phenylalkyl, or substituted (C7-C9)phenylalkyl, wherein the substituents on the substituted phenyl and substituted phenylalkyl are independently one or two of fluoro, chloro, (C1-C3)alkyl, (C1-C3)alkoxy, and trifluoro- methyl. The compounds are useful in treating inflammation or other leukotriene mediated diseases, including pulmonary, asthmatic, allergic, and gastrointestinal diseases.

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