2-amino-6-(2,4,5-substituted-phenyl)-pyridines for use as...

Details 2-amino-6-(2,4,5-substituted-phenyl)-pyridines for use as... 2-amino-6-(2,4,5-substituted-phenyl)-pyridines for use as...

C - Chemistry, Metallurgy

07

D

C07D 213/73 (2006.01) A61K 31/4418 (2006.01) A61K 31/4427 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2463364

The present invention relates to the compounds 6-[4-(N-methyl-3-azetidinoxy)-5- ethyl-2-methoxy-phenyl]-pyridin-2-ylamine, 6-[4-(N, N-dimethylaminomethyl)-5- ethyl-2-methoxy-phenyl]-pyridin-2-ylamine, 6-[4-(N-methylaminomethyl)-5-ethyl- 2-methoxy-phenyl]-pyridin-2-ylamine, 6-[4-(3-azetidinoxy)-5-ethyl-2-methoxy- phenyl]-pyridin-2-ylamine and 6-[4-(2-dimethylamino-ethoxy)-5-ethyl-2-methoxy- phenyl]-pyridin-2-ylamine, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing such compounds and to the use of such compounds as nitric oxide synthase inhibitors in the treatment and prevention of central nervous system and other disorders.

La présente invention concerne les composés 6-[4-(N-méthyl-3-azétidinoxy)-5-éthyl-2-méthoxy-phényl]-pyridin-2-ylamine, 6-[4-(N, N-diméthylaminométhyl)-5-éthyl-2-méthoxy-phényl]-pyridin-2-ylamine, 6-[4-(N-méthylaminométhyl)-5-éthyl-2-méthoxy-phényl]-pyridin-2-ylamine, 6-[4-(3-azétidinoxy)-5-éthyl-2-méthoxy-phényl]-pyridin-2-ylamine et 6-[4-(2-diméthylamino-éthoxy)-5-éthyl-2-méthoxy-phényl]-pyridin-2-ylamine, ainsi que les sels pharmaceutiquement acceptables de ces derniers, des compositions pharmaceutiques contenant de tels composés et l'utilisation de ces mêmes composés en tant qu'inhibiteurs de la synthase d'oxyde nitrique dans le traitement et la prévention des troubles du système nerveux central et autres.

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