2-amino-6-anilino-purines and their use as medicaments

Details 2-amino-6-anilino-purines and their use as medicaments 2-amino-6-anilino-purines and their use as medicaments

C - Chemistry, Metallurgy

07

D

C07D 473/16 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01) C07D 473/40 (2006.01)

Patent

CA 2360353

2-Amino-6-anilino-purine derivatives of formula (I) in which R1 is -S(O)k- NR6R7 or-N(aryl lower alkyl) carbamoyl or -NH-S(O)i-R8 or -NH-C(O)-R9; 9 is 1- 5; These compounds inhibit p34cdc2/cyclin Bcdc13 kinase and protein tyrosine kinase pp60c-src and can be used for treatment of hyperproliferative diseases, for example tumour diseases, and diseases which respond to inhibition of the activity of protein tyrosine kinase pp60c-src, in particular osteoporosis.

L'invention concerne des dérivés 2-amino-6-anilino-purine de formule (I), dans laquelle R¿1? représente S(O)¿k?-NR¿6?R¿7?, ou N(aryle alkyle inférieur) carbamoyle, ou NH-S(O)i-R¿8?, ou NH-C(O)-R¿9?; et 9 varie entre 1 et 5. Ces composés, qui inhibent la p34?cdc2¿/cycline B?cdc13¿ kinase et la protéine tyrosine kinase pp60?c-src¿, peuvent être utilisés pour traiter les maladies hyperprolifératives, par exemple les affections tumorales et les maladies répondant à l'inhibition de l'activité de ladite protéine tyrosine kinase pp60?c-src¿, en particulier l'ostéoporose.

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