2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

Details 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones 2-amino-7,8-dihydro-6h-pyrido[4,3-d] pyrimidin-5-ones

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 211/86 (2006.01)

Patent

CA 2624253

Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5- one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro- 6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nevous system diseases.

L'invention concerne des composés de 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidine-5-one, leurs stéréoisomères, des tautomères, des sels pharmaceutiquement acceptables et des promédicaments de ceux-ci ; des compositions qui comprennent un support pharmaceutiquement acceptable et un ou plusieurs des composés de 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidine-5-one, soit seuls, soit en combinaison avec un ou plusieurs agents thérapeutiques supplémentaires. L'invention présente aussi des procédés utilisant les composés de 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidine-5-one, soit seuls, soit en combinaison avec un ou plusieurs agents thérapeutiques supplémentaires, dans la prophylaxie ou le traitement de maladies à prolifération cellulaire, virales, autoimmunes, cardiovasculaires et du système nerveux central.

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