2-amino-7-hydroxytetralin carboxyalkyl ethers

C - Chemistry – Metallurgy – 07 – C

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167/252, 167/260

C07C 229/46 (2006.01) A61K 31/215 (2006.01) C07C 217/74 (2006.01) C07C 271/24 (2006.01)

Patent

CA 2009992

IN THE CANADIAN PATENT & TRADEMARK OFFICE PATENT APPLICATION entitled: 2-Amino-7-hydroxytetralin carboxyalkyl ethers. in the names of: Umberto GUZZI Roberto CECCHI Assiqnee: SANOFI ABSTRACT OF THE DISCLOSURE The invention relates to 2-amino-7-hydroxytetralin carboxy- alkyl ethers of formula Image (I) wherein Alk represents a straight or branched (C3-C5)alky- lene group, and R is hydrogen or (C1-C4)alkyl, useful as starting materials in the synthesis of 7-substituted phenylethanolaminotetralins of formula (XII) Image Image (XII) wherein X represents hydrogen, halogen, (C1-C4)alkyl, or trifluoromethyl which are useful as spasmolytics. The new 7-substituted phenylethanolaminotetralins (XII) as well as the intermediates in the preparation of the com- pounds (I), the N-protected 2-amino-7-hydroxytetralin carboxyalkyl ethers, are also claimed.

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