2-amino- and 2-thio-substituted 1,3-diaminopropanes

Details 2-amino- and 2-thio-substituted 1,3-diaminopropanes 2-amino- and 2-thio-substituted 1,3-diaminopropanes

C - Chemistry, Metallurgy

07

C

C07C 233/36 (2006.01) C07C 323/41 (2006.01) C07D 335/04 (2006.01)

Patent

CA 2560773

Disclosed are compounds of the formula: where variables Q, Z, X, R15, R2, R3, and Rc are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer~s disease and other diseases characterized by deposition of A beta peptide in a mammal.

L'invention concerne des composés de formule (I), dans laquelle les variables Q, Z, X, R15, R2, R3 et Rc sont telles que définies dans la description. Lesdits composés sont des inhibiteurs de l'enzyme bêta-sécrétase et sont par conséquent utiles dans le traitement de la maladie d'Alzheimer et d'autres maladies caractérisées par le dépôt d'un peptide bêta-amlyoïde chez un mammifère.

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