C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 407/06 (2006.01) A61K 31/4709 (2006.01) A61P 25/28 (2006.01) C07D 407/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2714008
The present invention is directed to novel 2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and / or dementia. The compounds of the present invention are inhibitors of .beta.-secretase, also known as .beta.-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.
La présente invention concerne de nouveaux dérivés de 2-amino-quinoline, des compositions pharmaceutiques contenant ceux-ci et leur utilisation dans le traitement de la maladie d'Alzheimer (AD), des troubles cognitifs légers, de la sénilité et/ou de la démence. Les composés de la présente invention sont des inhibiteurs de la ß-sécrétase, également désignée sous le nom d'enzyme de clivage de l'amyloïde ß, BACE, BACE1, Asp2, ou mémapsine2.
Baxter Ellen
Creighton Christopher J.
Lu Tianbao
Luo Chi
Morgan Ross Tina
Janssen Pharmaceutica N.v.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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