C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/18 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/506 (2006.01) A61P 25/16 (2006.01) C07D 295/13 (2006.01) C07D 295/15 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2465695
The invention concerns the use of 2-amino-thiazoline derivatives of formula (I), wherein: Y is a (CH¿2?) methylene and X is selected among the following groups: O, NH, C¿1?-C¿4? N-alkyl, N-Bn, N-Ph, N-(2-Py), N-(3-Py), N(4-Py), N-2-pyrimidyl, N-5-pyrimidyl, S, SO, SO¿2?, CH¿2? or CHPh; or Y is a (C=O) carboxy and X is selected among the following groups: NH, N-Ph, N-(2-Py), N-(3-Py), N(4-Py), N-2-pyrimidyl, N-5-pyrimidyl, or their pharmaceutically acceptable salts as inhibitors of inducible NO-synthase.
La présente invention concerne l'utilisation de dérivés 2-amino-thiazoline de formule (I) dans laquellesoit Y est un méthylène (CH2) et X est choisi parmi les groupement suivants : O, NH, N-Alkyle(C1-C4), N-Bn, N-Ph, N-(2-Py), N-(3- Py), N-(4-Py), N-2-pyrimidyle, N-5-pyrimidyle, S, SO, SO2, CH2 ou CHPh ; soit Y est un carboxy (C=O) et X est choisi parmi les groupements suivants : NH, N- Ph, N-(2-Py), N-(3-Py), N-(4-Py), N-2-pyrimidyle ou N-5-pyrimidyle ou leurs sels pharmaceutiquement acceptables comme inhibiteurs de NO-synthase inductible.
Bigot Antony
Carry Jean-Christophe
Mignani Serge
Aventis Pharma S.a.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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