A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/137 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2623092
Use of a compound for the manufacture of a medicament for use in therapy of a neurodegenerative condition, wherein the compound is of formula (I): wherein R1 is CHR4-OR5 or CHR4-SR5, or aryl or heteroaryi optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is part of a ring with R5; R5 is aryl or heteroaryi optionally substituted with R7; each R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyl, CH2S02alkyl or OCONalkyl2; R7 is R8 or (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryl, NHSO2Me, CONH2, SMe, SOMe or SO2NH2; R8 is (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9or (CH2)nCOaryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof.
La présente invention concerne un composé destiné à la fabrication d~un médicament destiné à être utilisé dans le traitement d~une maladie neurodégénérative. Ce composé répond à la formule(I): où R1 est CHR4-OR5 ou CHR4-SR5, ou aryle ou hétéroaryle factulativementfacultativement substitué par un ou plusieurs groups R6; R2 est alkyle ou fait partie d~un cycle avec R3; R3 est H, alkyle ou CH2 (lorsqu~il fait partie d~un cycle avec R2); R4 est H ou alkyle ou fait partie d~un cycle avec R5; R5 est aryle ou hétéroaryle facultativement substitué par R7; chaque R6 est indépendamment alkyle, CF3, OH, Oalkyle, OCOalkyle, CONH2, CN, halogène, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyle, CH2S02alkyle ou OCONalkyl2; R7 est R8 ou (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogène, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryle, NHSO2Me, CONH2, SMe, SOMe ou SO2NH2; R8 est (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9 ou (CH2)nCOaryle; R9 est alkyle ou cycloalkyle; et n est 1 à 4; ou un sel de celui-ci.
Bannister Robin Mark
Lyne Michael Harvey
Biocopea Limited
Sosei R&d Ltd.
Torys Llp
LandOfFree
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