2-aminoalkylaminoquinolines as dopamine d4 ligands

C - Chemistry – Metallurgy – 07 – D

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C07D 401/12 (2006.01) A61K 31/47 (2006.01) C07D 215/38 (2006.01)

Patent

CA 2293480

A compound of formula (IA) or the pharmaceutically acceptable acid addition salts thereof wherein: R1, R2, R3, R4 and R5 are the same or different and represent hydrogen, halogen, C1-C6alkyl, C1-C4alkoxy, C1-C4alkylthio, hydroxy, amino, mono(C1-C6) alkylamino, di(C1-C6)alkylamino, cyano, nitro, trifluoromethyl or trifluoromethoxy; R6 is hydrogen or C1-C6alkyl; W is nitrogen, COH, or CH; Y and Z independently represent nitrogen or CH; and A represents an alkylene group of from 2-5 carbon atoms optionally substituted with one or more alkyl groups having from one to four carbon atoms. The compounds of the invention demonstrate high affinity and selectivity in binding to the D4 receptor subtype.

L'invention concerne un composé de formule (IA) ou des sels d'addition d'acide pharmaceutiquement acceptables de ceux-ci. Dans ladite formule (I), R¿1?, R¿2?, R¿3?, R¿4? et R¿5? sont identiques ou différents et représentent hydrogène, halogène, alkyle C¿1?-C¿6?, alcoxy C¿1?-C¿4?, alkylthio C¿1?-C¿4?, hydroxy, amino, monoalkylamino(C¿1?-C¿6?), dialkylamino(C¿1?-C¿6?), cyano, nitro, trifluorométhyle ou trifluorométhoxy; R¿6? représente hydrogène ou alkyle C¿1?-C¿6?; W représente azote, COH, ou CH; Y et Z représentent séparément azote ou CH; et A représente un groupe alkylène à 2 à 5 atomes de carbone éventuellement substitués par un ou plusieurs groupes alkyle à un à quatre atomes de carbone. Les composés de l'invention présentent une grande affinité et sélectivité dans la liaison au sous-type du récepteur de D¿4?.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

2-aminoalkylaminoquinolines as dopamine d4 ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-aminoalkylaminoquinolines as dopamine d4 ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-aminoalkylaminoquinolines as dopamine d4 ligands will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1584132

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.