2-aminoaryloxazole compounds as tyrosine kinase inhibitors

Details 2-aminoaryloxazole compounds as tyrosine kinase inhibitors 2-aminoaryloxazole compounds as tyrosine kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 263/48 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2542909

The present invention relates to novel compounds selected from 2- aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl, FGFR3 and/or Flt-3 inhibitors.

La présente invention concerne de nouveaux composés choisis parmi les 2-aminoaryloxazoles qui modulent, régulent, et/ou inhibent sélectivement la transduction de signaux induite par certaines tyrosine-kinases natives et/ou mutantes impliquées dans une variété de maladies affectant l'homme et l'animal, telles que les troubles de la prolifération cellulaire et les affections métaboliques, allergiques et dégénératives. Ces composés sont plus particulièrement des inhibiteurs puissants et sélectifs de c-kit, bcr-abl, FGFR3 et/ou Flt-3.

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