2-aminoethyl substituted pyrimidin-2-ones, cyclopropanes,...

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 239/22 (2006.01) A61K 31/135 (2006.01) A61K 31/415 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 31/554 (2006.01) C07C 225/18 (2006.01) C07D 231/06 (2006.01) C07D 239/26 (2006.01) C07D 281/10 (2006.01)

Patent

CA 2515706

The present invention provides a combinatorial approach to a library of novel compounds having four diversity points. The compounds provide for the mapping of urotensin II and somatostatin 5 receptors by differential binding of said receptors. Accordingly, the invention relates in a first aspect to novel compounds of the general formula I to V or salts thereof, The present invention further relates to a method of treating diseases for which modulation of the urotensin II receptor produces a physiologically beneficial response in said disease, such as those associated with CNS function and cardiovascular diseases. The present invention further relates to pharmaceutical compositions comprising these agents for the -treatment of these diseases adapted to modulate the urotensin II receptor.

La présente invention se rapporte à une approche combinatoire appliquée à une pharmacothèque de nouveaux composés possédant quatre points de diversité. Lesdits composés permettent d'établir une carte des récepteurs à l'urotensine II et à la somatostatine 5 par la liaison différentielle desdits récepteurs. L'invention a également trait à une méthode permettant de traiter des maladies dans lesquelles la modulation du récepteur à l'urotensine II génère une réponse physiologiquement bénéfique dans ladite maladie, telles que les maladies liées au fonctionnement du système nerveux central et les maladies cardiovasculaires. La présente invention concerne aussi des compositions pharmaceutiques contenant lesdits agents, qui sont destinées à traiter lesdites maladies et sont adaptées de manière à moduler le récepteur à l'urotensine II.

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