C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/88 (2006.01) A61K 31/4168 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/08 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/10 (2006.01) C07D 405/06 (2006.01) C07D 405/10 (2006.01) C07D 409/06 (2006.01) C07D 409/10 (2006.01) C07D 413/10 (2006.01)
Patent
CA 2714058
The present invention is directed to 2-aminoimidazole compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
La présente invention concerne des composés de 2-aminoimidazole représentés par la formule (I) qui sont des inhibiteurs de l'enzyme bêta-secrétase et qui sont utiles dans le traitement de maladies dans lesquelles est impliquée l'enzyme bêta-secrétase, telles que la maladie d'Alzheimer. Cette invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur l'utilisation de ces composés et de ces compositions dans le traitement de maladies dans lesquelles l'enzyme bêta-secrétase est impliquée.
Coburn Craig A.
Graham Samuel L.
Hills Ivory D.
Moore Keith P.
Nantermet Philippe G.
Merck Sharp & Dohme Corp.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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