2-aminoindans as selective dopamine d3 ligands

Details 2-aminoindans as selective dopamine d3 ligands 2-aminoindans as selective dopamine d3 ligands

C - Chemistry, Metallurgy

07

C

C07C 311/18 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/255 (2006.01) A61K 31/275 (2006.01) C07C 211/42 (2006.01) C07C 237/20 (2006.01) C07C 307/10 (2006.01) C07C 309/66 (2006.01) C07C 311/05 (2006.01) C07C 311/21 (2006.01) C07C 311/46 (2006.01) C07C 317/28 (2006.01) C07C 317/32 (2006.01) C07C 317/44 (2006.01) C07C 323/29 (2006.01) C07C 323/67 (2006.01) C07D 213/71 (2006.01)

Patent

CA 2208600

Compounds and their pharmaceutically acceptable salts suitable for treating central nervous system disorders associated with the dopamine D3 receptor activity of formula (I) wherein R1 and R2 are independently H, C1-8 alkyl or C1-8 alkylAryl; X is CH2R3 or NHSO2R4; Y is hydrogen, CH2R3, NHSO2R4, CONR1R2, SO2NR1R2, SO2CH3, halogen, OSO2CF3, SCH3 or OCH3; R3 is NHSO2R4, SO2R4, CONR1R2 or Aryl; and R4 is NR1R2, C1-C8 alkyl, Aryl or C1-C8 alkylAryl.

L'invention porte sur des composés et leurs sels acceptables du point de vue pharmaceutique se prêtant au traitement de troubles du système nerveux central associés à l'activité du récepteur de la dopamine D3. Ces composés sont représentés par la formule (I) dans laquelle R¿1? et R¿2? sont indépendamment hydrogène, alkyle en C¿1?-C¿8? ou alkylaryle en C¿1?-C¿8?, X est CH¿2?R¿3? ou NHSO¿2?R¿4?, Y est hydrogène, CH¿2?R¿3?, NHSO¿2?R¿4?, CONR¿1?R¿2?, SO¿2?NR¿1?R¿2?, SO¿2?H¿3?, halogène, OSO¿2?CF¿3?, SCH¿3? ou OCH¿3?, R¿3? est NHSO¿2?R¿4?, SO¿2?R¿4?, CONR¿1?R¿2? ou aryle et où R¿4? est NR¿1?R¿2?, alkyle en C¿1?-C¿8?, aryle ou un alkylaryle en C¿1?-C¿8?.

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