2-(aminomethyl)-3,4,7,9-tetrahydro-2h-pyrano-[2,3e]indol-8-o...

Details 2-(aminomethyl)-3,4,7,9-tetrahydro-2h-pyrano-[2,3e]indol-8-o... 2-(aminomethyl)-3,4,7,9-tetrahydro-2h-pyrano-[2,3e]indol-8-o...

C - Chemistry, Metallurgy

07

D

C07D 491/052 (2006.01) A61K 31/407 (2006.01) A61K 31/4741 (2006.01) A61K 31/55 (2006.01) A61P 25/18 (2006.01) C07D 491/04 (2006.01)

Patent

CA 2189525

Compounds of Formula I are selective autoreceptor agonists useful in treating disease states involving hyperactivity of dopamine systems: (See formula I) in which X is -(CH2)n-; n is 1-3; R1 is hydrogen, alkyl, hydroxyalkyl, cycloalkyl- methyl, bicyclo-alkylmethyl or -(CH2)m Y Ar; where m is 0-4, Y is -CH2-, and Ar is phenyl, halophenyl, alkylphenyl, dialkylphenyl or alkoxyphenyl; R2 is hydrogen or alkyl; R3 is hydrogen, halogen, alkyl, alkoxy or hydroxy; or a pharmaceutically acceptable salt thereof.

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