2-aminomethyl-4,6-dihalogenphenol derivatives and methods...

Details 2-aminomethyl-4,6-dihalogenphenol derivatives and methods... 2-aminomethyl-4,6-dihalogenphenol derivatives and methods...

C - Chemistry, Metallurgy

07

D

260/247, 260/492

C07D 295/04 (2006.01) C07D 295/088 (2006.01) C07D 295/096 (2006.01)

Patent

CA 1090340

ABSTRACT 2-aminomethyl-4,6-dihalogenphenol derivatives and salts thereof with physiologically acceptable acids or bases having the formula: Image or Image (I) (I') wherein X is the same halogen in both positions, R1 is a hydrogen atom or a lower alkyl group, R2 is an alkyl, cycloalkyl, aryl or aralkyl group, or R1 and R2 together with the nitrogen atom may form a saturated heterocyclic ring, which ring may be interrupted by an oxygen, nitrogen or sulfur atom, R3 is a hydrogen atom, an alkyl, alkoxyalkyl, carboxyalkyl, carbamylalkyl, aralkyl, acyl or sulfonyl group or a base radical, e.g. an alkali metal atom, and R3" is a cyanoalkyl, hydroxyalkyl, carbalkoxy-alkyl, N,N-dialkylcarbamyl, N-alkylcarbamyl-alkyl or N,N-dialkylcarbamylalkyl group, are useful as diur- etics and saluretics; some derivatives possess secretolytic activity.

203513

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