C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/276, 260/310
C07D 295/08 (2006.01) C07C 43/21 (2006.01) C07D 277/04 (2006.01) C07D 295/096 (2006.01) C07D 307/52 (2006.01)
Patent
CA 1238908
Abstract of the Disclosure The invention relates to 2-aminomethylphenols of the formula I Image (I) in which R represents hydrogen or alkyl having 1 or 2 C atoms, R1 represents alkyl, cycloalkyl, alkenyl or cyclo- alkenyl, it being possible for each of these radicals to be substituted with 1 to 5 halogen atoms, R2 and R4 denote hydrogen, halogen, alkyl or alkoxy, R3 denotes halogen, alkyl or cycloalkyl, R5 and R6 represent hydrogen, alkyl, cycloalkyl or the radical -[CH2](1 or 2)-Ar, which can be alkyl-substituted in the chain and wherein Ar is an aromatic or heteroaromatic system optionally substituted by alkyl, alkoxy and/or halogen, and n is 1 or 2, R5 and R6 and/or two of the radicals R2, R3 and R4 forming a -[CH2]m- chain with m = 3 to 6 which is optionally substituted by 1 or 2 methyl groups and which, in the case of R5 and R6, is also interrupted by oxygen atoms, sulfur atoms and/or imino groups, their physiologically tolerated salts, a process for their preparation, pharmaceutical formulations based thereon and their use as medicaments. The 2-aminomethylphenols of the formula I have saluretic properties.
422951
Englert Heinrich C.
Hropot Max
Kaiser Joachim
Lang Hans-Jochen
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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