2-aminopyrazine-5-carboxamide derivatives, their preparation...

Details 2-aminopyrazine-5-carboxamide derivatives, their preparation... 2-aminopyrazine-5-carboxamide derivatives, their preparation...

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/495 (2006.01) C07D 241/26 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01)

Patent

CA 2123668

- 33 - ABSTRACT 2-AMINOPYRAZINE-5-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS Compounds corresponding to the general formula (I) Image (I) in which n represents 0 or 1, R1 represents a methyl group, in which case R2 represents a phenoxy(C1-C4)alkyl group (in which the phenoxy group is optionally substituted), or else R1 and R2 together form, and with the nitrogen atom which carries them, a 4-(phenoxymethyl)piperid-1-yl group (in which the phenoxy group is optionally substituted) or a 4-phenylpiperazin-1-yl group (in which the phenyl group is optionally substituted), R3 represents a hydrogen atom or a methyl group, R4 represents a hydrogen atom and R5 represents a hydrogen atom or a group of general formula -CH2-CH2-NH-R6, R6 being a hydrogen atom or a tert-butyloxycarbonyl, 4-carbamoylpyrimidin-2-yl or 5-carbamoylpyrazin-2-yl group, are useful in the treatment of diseases and complaints involving hyperactivity of the .alpha.-adrenergic system at the level of the lower urinary apparatus.

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