2-aminopyridine derivative

Details 2-aminopyridine derivative 2-aminopyridine derivative

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61K 31/55 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2562602

A compound useful a remedy or a preventive for inflammatory diseases or autoimmune diseases in which IKK2 participate. Namely, a 2-aminopyridine derivative characterized by having a 2-hydroxyphenyl group at the 6-position and a saturated cyclic group containing a nitrogen atom such as piperidine at the 4-position. Because of having an excellent antiinflammatory effect based on an IKK2 inhibitory effect, the above compound or a medicinal composition thereof is useful as a remedy or a preventive for inflammatory diseases or autoimmune diseases, in particular, rheumatoid arthritis.

Composé utile comme remède ou médicament préventif pour des maladies inflammatoires ou des maladies auto-immunes dans lesquelles participe l'IKK2. A savoir dérivé de 2-aminopyridine caractérisé en ce qu'il a un groupe 2-hydroxyphényle en position 6 et un groupe cyclique saturé contenant un atome d'azote tel qu'un groupe pipéridine en position 4. Du fait qu'il a un excellent effet anti-inflammatoire basé sur un effet d'inhibition de l'IKK2, le composé ci-dessus ou une composition médicinale de celui-ci est utile comme remède ou médicament préventif pour des maladies inflammatoires ou des maladies auto-immunes, en particulier pour la polyarthrite rhumatoïde.

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