2-aminopyrimidine derivatives as raf kinase inhibitors

Details 2-aminopyrimidine derivatives as raf kinase inhibitors 2-aminopyrimidine derivatives as raf kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/155 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07C 279/18 (2006.01)

Patent

CA 2529090

This application discloses compounds that inhibit Raf kinase having the formula (I), wherein R1 is a phenyl radical or a heteroaryl radical; and R2 is a phenyl radical; or an N-oxide or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of proliferative diseases, such as cancer.

L'invention concerne des composés inhibant la Raf kinase représentés par la formule (I) ou un N-oxyde ou un sel pharmaceutiquement acceptable de celui-ci. Dans la formule (I), R¿1? représente un radical phényle ou un radical hétéroaryle; et R¿2? représente un radical phényle. On utilise ces composés pour traiter les maladies prolifératives, telles que le cancer.

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