2-aminoquinoline derivatives

Details 2-aminoquinoline derivatives 2-aminoquinoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/506 (2006.01) A61K 31/55 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 15/00 (2006.01) A61P 15/06 (2006.01) A61P 15/08 (2006.01) A61P 17/00 (2006.01) A61P 19/06 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/08 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006

Patent

CA 2526374

A 2-aminoquinoline derivative represented by the general formula [I]: wherein R1 and R2 each represents lower alkyl, lower cycloalkyl, etc. or R1 and R2 in combination form an aliphatic nitrogenous heterocycle in cooperation with the nitrogen atom bonded to these; R3, R4 , R5, R6, and R7 each represents hydrogen, lower alkyl, etc.; R8 represents lower alkyl, lower alkyloxy, etc.; and n is an integer of 0 to 4. The compound functions as a melanin- concentrating hormone receptor antagonist and is useful as a medicine for central diseases, circulatory diseases, or metabolic diseases.

L'invention concerne un dérivé de 2-aminoquinoline représenté par la formule générale [I] dans laquelle R?1¿ et R?2¿ représente chacun un alkyle inférieur, un cycloalkyle inférieur, etc., ou R?1¿ et R?2¿ combinés forment un hétérocycle aliphatique azoté en coopération avec l'atome d'azote lié à ceux-ci; R?3¿, R?4¿, R?5¿, R?6¿ et R?7 ¿représentent chacun hydrogène, un alkyle inférieur, etc.; R?8¿ représente un alkyle inférieur, un alkyloxy inférieur, etc; et n est un entier de 0 à 4. Ce composé est un antagoniste du récepteur de l'hormone de concentration de la mélanine, et est utilisé comme médicament contre les maladies du système nerveux central, les maladies circulatoires, ou les maladies métaboliques.

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