2-aminosugar derivatives of macrolides

Details 2-aminosugar derivatives of macrolides 2-aminosugar derivatives of macrolides

C - Chemistry, Metallurgy

07

H

C07H 19/01 (2006.01) A61K 31/70 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2131373

Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I). wherein n is 1 or 2; A and B are taken together and form = O or A and B are taken separately and are each H or A is OH and B is H; R1 is a 2-aminoglycosyl group; R2 is OH or a glycosyloxy group; and R3 is an alkyl or allyl group.

Divulgation de macrolides de formule (I) et de méthodes de traitement du rejet de greffes, des infections fongiques et des maladies auto-immunitaires, comme la polyarthrite rhumatoïde et le psoriasis, avec ces macrolides de formule (I), dans laquelle n est 1 ou 2; A et B forment ensemble = O, ou A et B sont pris séparément et sont indépendamment l'un de l'autre H, ou A est OH, et B est H; R1 est un groupement 2-aminoglycosyle; R2 est OH ou un groupement glycosyloxy; et R3 est un groupement alkyle ou allyle.

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