C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/60 (2006.01)
Patent
CA 2561267
The present invention is directed to 2-aminothiazole compounds which are aspartyl protease inhibitors, and are inhibitors of both the beta-secretase enzyme and HIV protease, and that are useful in the treatment of diseases in which the beta-secretase enzyme and HIV are involved, such as Alzheimer's disease, HIV Infection and AIDS. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta- secretase enzyme and HIV protease are involved.
L'invention concerne des composés 2-aminothiazole qui sont des inhibiteurs de l'aspartyle-protéase, et sont à la fois des inhibiteurs de la bêta-sécrétase, et de la protéase du VIH. Ces composés peuvent ainsi servir au traitement de maladies liées à la bêta-sécrétase et au VIH, telles que la maladie d'Alzheimer, l'infection VIH et le SIDA. L'invention concerne en outre des compositions pharmaceutiques contenant ces composés, et l'utilisation de ces composés et de ces compositions pour le traitement des maladies liées à la bêta-sécrétase et à la protéase du VIH.
Coburn Craig A.
Espeseth Amy S.
Hazuda Daria J.
Holloway M. Katharine
Olsen David B.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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