2- and 8-azido (2'-5')oligoadenylates and antiviral uses...

Details 2- and 8-azido (2'-5')oligoadenylates and antiviral uses... 2- and 8-azido (2'-5')oligoadenylates and antiviral uses...

C - Chemistry, Metallurgy

07

H

167/202, 195/1.1

C07H 21/00 (2006.01) A01N 57/16 (2006.01) A61K 31/70 (2006.01)

Patent

CA 1334174

Compounds of the formula Image wherein m is 0, 1, 2 or 3; n is 0, 1, 2 or 3; and each R1 and each R2 is, independently of each other R1 and R2, hydrogen or N3, provided at least one R1 or R2 is N3; and water soluble salts thereof. Compounds of the formula activate RNase L, leading to the cleavage of viral mRNA or rRNA, thereby inhibiting viral protein synthesis. They also have activity against plant-infecting viruses. The compounds, upon UV irradiation, form nitrene free radical intermediates which are capable of covalently photoinsert- ing into (or cross-linking) biological molecules.

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