2-anilino-4-aminoalkyleneaminopyrimidines

Details 2-anilino-4-aminoalkyleneaminopyrimidines 2-anilino-4-aminoalkyleneaminopyrimidines

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/4178 (2006.01) A61K 31/425 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2655315

The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-a). The PKC-a inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.

La présente invention concerne des inhibiteurs de type 2-arylamino-4-(aminoalkylène)aminopyrimidine qui sont des inhibiteurs et qui inhibent donc la Protéine Kinase C-alpha (PKC-.alpha.). Les inhibiteurs de PKC-.alpha. selon la présente invention jouent un rôle important dans l'amélioration du cycle myocardique du calcium intracellulaire, ce qui permet d'obtenir des performances améliorées en termes de contraction et de relaxation du myocarde et ralentit la progression d'un arrêt cardiaque. La présente invention concerne en outre des compositions comprenant lesdites 2-arylamino-4-(aminoalkylène)amino-pyrimidines ainsi que des méthodes de contrôle, de soulagement ou de ralentissement de la progression d'un arrêt cardiaque.

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