C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/14 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/395 (2006.01) C07C 229/42 (2006.01) C07D 207/337 (2006.01) C07D 213/55 (2006.01) C07D 215/18 (2006.01) C07D 233/64 (2006.01) C07D 235/12 (2006.01) C07D 235/16 (2006.01) C07D 307/54 (2006.01) C07D 333/24 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2067135
2067135 9106539 PCTABS00005 The are disclosed compounds of formulae (I) or (II), wherein R is hydroxy, lower alkoxy or lower alkoxyamino; one of R1 and R2 is A(CH2)nO-, the other is hydrogen; n is 1 - 2; A is phenoxyethyl, phenoxyphenyl or a group having formula (a), wherein X is -N= or (b); z is (c), (d), (e), (f), -S- or -O-; R3 is hydrogen, lower alkyl or phenyl; R4 is hydrogen or lower alkyl; or R3 and R4 taken together form a benzene ring optionally substituted by halogen; in which case the point of attachment of A to the rest of the molecule may be from this ring; R5 is hydrogen or lower alkyl and each may be the same or different; R6 is hydrogen, halo or lower alkyl and each may be the same or different; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.
Failli Amedeo A.
Kreft Anthony F. III
Musser John H.
American Home Products Corporation
Failli Amedeo A.
Kreft Anthony F. III
Musser John H.
Ridout & Maybee Llp
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