C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2696200
The invention relates to chemical compounds of the formula (I), or a pharmaceutically acceptable salt thereof, which possess inhibitory activity against the spindle checkpoint kinase: Tyrosine Threonine Kinase (TTK)/monopolar spindle 1 (Mpsl) and are accordingly useful for their anti-cancer effect in a warm-blooded animal such as man. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them, and to their use in the manufacture of a medicament for the treatment of conditions mediated by TTK/Mpsl, for use either alone or in combination with other anti-pro liferative agents.
L'invention porte sur des composés chimiques représentés par la formule (I), ou sur un sel pharmaceutiquement acceptable de ceux-ci, qui possèdent une activité inhibitrice contre la kinase de repère de fuseau : tyrosine thréonine kinase (TTK)/fuseau monopolaire 1 (Mps1) et sont, en conséquence, utiles pour leur effet anticancéreux chez un animal à sang chaud tel que l'homme. L'invention porte également sur des procédés de fabrication desdits composés chimiques, sur des compositions chimiques les contenant, et sur leur utilisation pour la fabrication d'un médicament destiné au traitement de pathologies médiées par TTK/Mps1, les composés pouvant être utilisés soit seuls, soit combinés à d'autres agents anti-prolifératifs.
Andrews David Michael
Jones Clifford David
Simpson Iain
Ward Richard Andrew
Astrazeneca Ab
Fetherstonhaugh & Co.
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