2-aroyl-4-acyl paclitaxel (taxol) analogs

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/335 (2006.01) A61K 31/365 (2006.01) C07D 305/14 (2006.01) C07D 317/70 (2006.01) C07D 493/10 (2006.01)

Patent

CA 2328771

2-debenzoyl-4-deacetyl paclitaxel, antineoplastic analogs thereof and intermediates are taught, as well as the formation of the compound, analogs and intermediates. The compound, analogs and intermediates may be used to form pharmaceutical compositions having anti-neoplastic activity. Further, the compound, analogs and intermediates may be used to treat cancer when applied in an effective amount by means such as a pharmaceutical composition.

L'invention concerne 2-débenzoyl-4-déacétyl paclitaxel, ses analogues antinéoplasiques et ses intermédiaires ainsi que la fabrication de ces composés, analogues et intermédiaires. On peut utiliser lesdits composés, analogues et intermédiaires pour former des compositions pharmaceutiques possédant une activité antinéoplasique. En outre, ces composés, analogues et intermédiaires peuvent servir à traiter le cancer lorsqu'on les applique dans des quantités efficaces, par exemple dans une composition pharmaceutique.

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