2-aroylimidazole compounds for treating cancer

Details 2-aroylimidazole compounds for treating cancer 2-aroylimidazole compounds for treating cancer

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/435 (2006.01) A61K 31/437 (2006.01) A61K 31/44 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 519/00 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2460345

Disclosed is a compound represented by Structural Formula (I). R1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl group. Zl is =0, =S, =NOR11, or =NR11. R is represented by a Structural Formula selected from formulas (II)-(VII). The variables in Structural Formulas (II)-(VII) are described below. These 2- aroylimidazole compounds are cytotoxic against cancer cells, including multi- drug resistant cancer cells, from a number of different tissue types.

L'invention concerne un composé représenté par la formule développée (I). R¿1? représente un groupe 2-imidazoyle substitué ou non substitué qui est éventuellement condensé avec un groupe aryle substitué ou non substitué. Z¿l? représente =0, =S, =NOR¿11?, ou =NR¿11?. R est représenté par une formule développée choisie parmi les formules (II), (III), (IV), (V), (VI), (VII). Les variables des formules développées (II)-(VII) sont définies dans le descriptif.

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