2-aryl-3-aminoaryloxynaphthyl compounds, intermediates,...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/13 (2006.01) A61K 31/135 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) A61K 31/21 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 31/56 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) C07C 205/38 (2006.01) C07C 217/90 (2006.01) C07C 233/25 (2006.01) C07C 237/08 (2006.01) C07C 309/65 (2006.01) C07C 311/32 (2006.01) C07D 207/09 (2006.01) C07D 295/088 (2006.01) C07D 295/15 (2006.01)

Patent

CA 2217810

The present invention provides pharmaceutically active compounds formula I (see fig. I) or a pharmaceutically acceptable salt or solvate thereof having activity as selective estrogen receptor modulators, pharmaceutical compositions containing the compounds, and methods of using formula I compounds for treating conditions resulting from estrogen deprivation or the inappropriately high presence of estrogen. Also provided are methods and chemical intermediates for the production of compounds of formula I above.

L'invention porte sur des composés possédant une activité pharmaceutique, de formule I (voir fig. I), ou sur un de leurs sels ou produits de solvatation, acceptables en pharmacie, modulateurs sélectifs des récepteurs d'oestrogènes; compositions pharmaceutiques renfermant ces composés et méthodes pour utiliser les composés de formule I pour traiter les troubles causés par la carence en oestrogènes ou la présence anormalement élevée d'oestrogènes. Sont également présentés les méthodes et les intermédiaires chimiques pour la préparation des composés de formule I ci-dessus.

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